Psilocybin for phantom limb pain

Renewed interest in the therapeutic potential of psychedelics has lead scientists to revisit research into how psilocybin might help phantom limb pain and other health challenges experienced by amputees.

LSD was first investigated as a treatment for PLP over 50 years ago, just as similar studies found that psilocybin, mescaline, and other plant-based compounds could help treat deep depression, PTSD, and chronic pain.

Evan Lewis, Head of Neurology at Numinus, tells Amplitude magazine:

“Disorders of phantom limb are disorders of the brain over predicting the phenomena that is there. It’s a mismatch with what the brain is seeing, and the only way the brain can tell you that is through pain. What psychedelics do is smooth out and reduce your predictions. A window of opportunity opens up to help you begin to reprogram your predictions.”

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